When people hear about uric acid, it’s almost always in the context of it being a causal factor for gout.
But if more people knew the full extent of how it affects our metabolism, cardiovascular health, and risk for Alzheimer’s and dementia, we might pay more attention to it.
In this episode of Health Theory, Dr. David Perlmutter returns with the latest research on how uric acid is about much more than just gout.
He explains the relationship between uric acid, insulin, and fructose, why it doesn’t mean that all fruits are bad for you, and how our modern problem with uric acid is actually the result of a disconnect between evolution and environment.
If you want to dive deeper into the latest knowledge bomb from Dr. Perlmutter, you’ll definitely want to check out his new book, Drop Acid: The Surprising New Science of Uric Acid The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health
SHOW NOTES: 00:00 | Introduction 00:43 | Uric Acid and Metabolism 06:42 | The Problem With Fructose 12:22 | What Does Uric Acid Do? 23:58 | Eat to Lower Uric Acid 33:43 | The Cause of Type 2 Diabetes 41:48 | The Ideal Diet & Lifestyle
QUOTES: “A lot of roads lead to the Rome of inflammation, and set the stage for things like Alzheimer's and coronary artery disease. And because of that, it's the reason that a monotherapy or a one drug approach to Alzheimer's, for example, is beyond myopic. It's never going to work.” [03:02]
“Our metabolic health globally is in a terrible place. I mean, a third of American adults have hypertension, and 10% of kids aged 12 to 18 have hypertension. That's crazy. 50% of adult Americans will be obese by the year 2030. Not just overweight, but obese.” [04:16]
“Elevation of uric acid is associated with an 80% increased risk of dementia, a 55% increase risk of Alzheimer's specifically, and a 165% increased risk of vascular dementia.” [13:53]
“What would be the upside of having uric acid create insulin resistance, and therefore cause blood sugar to go up? Why? Because when you're starving, it'll help power your brain.” [16:50]
“What we're seeing now are these metabolic derangements that underlie these diseases that represent a disconnect between evolution and environment.” [22:06]
“If it has a barcode, and it's in the grocery store, it has added sweetener 70% do. And by and large that comes from high fructose, there's the villain corn syrup that we subsidize to the tune of $500 billion a year.” [25:01]
“Uric acid levels are climbing in lockstep with fructose consumption. In the 1920s, average uric acid level in Americans was about 3.5 it's now six.” [46:50]